Summary
Scientists have found six new genetic links related to severe morning sickness called hyperemesis gravidarum (HG). In a large study, researchers from the University of South Carolina and other international collaborators analyzed genetic data from nearly half a million women to understand the genetic causes of HG.
Key Facts
- The study was conducted by researchers from the University of South Carolina alongside international collaborators.
- Researchers examined genetic data from about 10,974 women with HG and 461,461 women without it.
- HG affects about 2% of pregnant women causing extreme nausea and vomiting.
- The study identified a total of 10 genes linked to HG, including six new ones.
- One of the newly identified genes, TCF7L2, is also a known risk factor for type 2 diabetes.
- The researchers found that some genes linked to HG are also related to other pregnancy complications.
- The findings suggest new ways to treat HG by potentially tailoring therapies to a woman's genetic profile.
- A trial will test if using the diabetes drug metformin before pregnancy could help reduce HG symptoms.
