Weight-loss drugs tested in first head-to-head trial - and there's a clear winner
Summary
The first direct comparison between two weight-loss drugs, Mounjaro and Wegovy, found that Mounjaro helped people lose more weight. After 72 weeks, participants using Mounjaro lost about 20% of their body weight, while those on Wegovy lost around 14%.Key Facts
- The trial compared two weight-loss drugs: Mounjaro (tirzepatide) and Wegovy (semaglutide).
- Mounjaro led to a 20% weight reduction, while Wegovy resulted in a 14% reduction after 72 weeks.
- Both drugs work by making people feel full, leading to eating less and burning stored fat.
- Mounjaro affects two appetite pathways in the brain, while Wegovy affects one.
- The trial involved 750 obese participants with an average weight of 113kg.
- Results showed 32% of Mounjaro users lost a quarter of their body weight, compared to 16% for Wegovy users.
- Mounjaro users lost more from their waistlines and showed improved blood pressure, blood sugar, and cholesterol levels.
- Both drugs had similar side effects, and women generally lost more weight than men.
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