Smart drug that strips cancer cells of ‘invisibility cloak’ can shrink tumours by 30%, trial shows
Summary
A new drug called GRWD5769 helps the immune system find and attack cancer cells that try to hide from treatment. In an early trial with 83 patients, the drug, combined with immunotherapy, shrank tumors by at least 30% in several common cancer types.Key Facts
- GRWD5769 is a smart drug that removes an “invisibility cloak” from cancer cells, making them easier for the immune system to detect.
- The drug was tested with immunotherapy drug cemiplimab in 83 patients with cervical, bladder, liver, bowel, lung, or head and neck cancers.
- Tumors shrank in 26 patients, with 15 experiencing a reduction of at least 30%.
- Most patients had cancers that had stopped responding to previous treatments.
- GRWD5769 works by blocking an enzyme called ERAP1, which cancer cells use to hide from immune cells called T-cells.
- The trial was conducted across the UK, France, Spain and Australia and presented at a major cancer conference.
- The drug is taken as a tablet that patients can use at home and was well tolerated with few side effects.
- Further larger studies are planned to confirm these early promising results.
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