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Life-prolonging drug for advanced ovarian cancer gets go-ahead in England

Life-prolonging drug for advanced ovarian cancer gets go-ahead in England

Summary

NHS England has approved a new drug called mirvetuximab soravtansine (Elahere) to treat a specific type of advanced ovarian cancer that is resistant to standard chemotherapy. This drug targets cancer cells with a specific protein and has been shown to slow cancer growth and extend patients’ lives by several months.

Key Facts

  • Mirvetuximab soravtansine is the first new drug approved in over 20 years for resistant ovarian cancer.
  • The drug targets tumors with the folate receptor-alpha (FRα) protein and treats platinum-resistant ovarian, peritoneal, or fallopian tube cancers.
  • It is given by intravenous drip every three weeks.
  • A global study at eight NHS hospitals showed the drug delayed cancer progression and extended survival by about four months compared to chemotherapy.
  • About 37% of patients saw tumor shrinkage of at least 30% with this drug, compared to 16% with chemotherapy.
  • Up to 400 women in England a year could benefit from this treatment.
  • The drug combines an antibody that locates cancer cells and a molecule that kills them from inside.
  • NHS England and cancer experts call this a major advance offering new hope to patients with few options.
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