Lupus patients in England in remission after pioneering NHS trial of GM therapy
Summary
Five lupus patients in England went into remission after receiving a new treatment called CAR T-cell therapy, which uses the patients' own genetically changed immune cells. This therapy, tested in an NHS trial, may offer a long-lasting cure by resetting the immune system and reducing the need for ongoing medication.Key Facts
- CAR T-cell therapy changes a patient's own T cells to target and destroy disease.
- The treatment was applied to nine severe lupus patients in a trial led by University College London hospitals.
- Five patients on a lower dose of the therapy entered remission within months and stayed well for about 11 months.
- Three patients on a higher dose have been followed for three months with hopeful early results.
- The therapy improved kidney function and other lupus symptoms.
- Lupus is an autoimmune disease that causes the immune system to attack healthy organs and tissues.
- About 5 million people worldwide have lupus, mostly women.
- One patient, Katie Tinkler, experienced major improvements, no longer having symptoms after decades and returning to activities like skiing and dancing.
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