Scientists Followed 800 Adults Over 90. One Group Had Double Dementia Risk
Summary
Researchers studied over 800 adults aged 90 and older to understand dementia risk in very old age. They found that risk varies by sex, race, ethnicity, and genetics, with women and certain racial groups having higher chances of developing dementia even after age 90.Key Facts
- The study followed adults aged 90+ as part of the LifeAfter90 project by UC Davis Health and Kaiser Permanente.
- Women were about twice as likely to develop dementia as men after age 90.
- Black participants had a 75% higher risk of dementia compared to Asian participants.
- Black and Hispanic individuals had higher rates of dementia than White and Asian groups.
- The APOE gene, linked to Alzheimer’s disease, affects dementia risk differently in very old adults.
- The APOE2 gene variant reduced dementia risk by about 60%, even after age 90.
- APOE4 gene increased dementia risk mostly in men and Black participants.
- Some people stayed healthy cognitively despite risk factors like high blood pressure or carrying APOE4.
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