Most powerful obesity drug yet: People lost up to 25% of weight in trial
Summary
A new obesity drug called retatrutide helped people lose up to 25 percent of their body weight in a clinical trial lasting 80 weeks, with even greater weight loss after about two years. The drug also improved health problems related to obesity, like knee pain, sleep apnea, and measures of heart and metabolic health.Key Facts
- Retatrutide was tested in a trial with 2,339 participants across 11 countries.
- Participants lost an average of 25 percent of their body weight on the highest dose after 80 weeks, increasing to 30 percent after 104 weeks.
- Over a third of patients lost 30 percent or more of their weight.
- The drug reduced knee pain by up to 62 percent in participants with knee osteoarthritis linked to obesity.
- It lowered obstructive sleep apnea events by up to 57 percent in affected participants.
- Retatrutide improved blood pressure, triglycerides (blood fats), and bad cholesterol (LDL).
- More than 90 percent of participants with prediabetes saw the condition resolve by the end of the trial.
- Retatrutide combines three hormones (GLP-1, GIP, and glucagon) to control appetite, blood sugar, and metabolism, improving on earlier obesity drugs.
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