Antidepressant escitalopram more effective at preventing relapse, analysis finds
Summary
An analysis of studies involving nearly 10,000 people found that escitalopram performed best among the antidepressants examined at preventing depression relapse, with agomelatine and duloxetine also ranking well. Researchers and clinicians said the differences were modest and do not show which medicine will work best for any one person; patients should discuss treatment choices with their doctors.Key Facts
- The analysis examined previous studies comparing more than a dozen antidepressants.
- People taking escitalopram were more likely than those taking fluoxetine (Prozac) to improve and remain well, and less likely to stop their medication.
- Agomelatine and duloxetine ranked next after escitalopram in the analysis.
- The researchers said the differences between medicines were modest and that longer studies are needed.
- Experts said treatment decisions should consider factors such as side effects, a patient's previous response and their preferences.
- Escitalopram can cause side effects, including sleep problems, constipation and weight gain.
- Doctors commonly recommend continuing antidepressants for at least six months after depression symptoms end, then reducing the dose gradually.
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