Scientists Wipe Out Deadly Childhood Brain Tumors in Every Mouse Tested
Summary
Researchers at UC San Francisco reported that an experimental immune-cell treatment eliminated diffuse midline glioma tumors in every treated mouse in two models of the childhood cancer. The therapy uses a brain signal to activate cancer-targeting cells, but it has not yet been tested in people, and researchers are working toward human testing.Key Facts
- Diffuse midline glioma grows in the brainstem and has few effective treatment options.
- The experimental therapy, called B-SYNC CAR-T, genetically modifies T cells to target tumor proteins EphA2 or IL13Rα2.
- B-SYNC cells use the brain protein brevican as a signal to switch on their cancer-targeting receptors.
- After researchers delivered the cells into the brain's fluid-filled ventricles, the treatment eliminated tumors in every treated mouse in two models.
- Conventional CAR-T cells did not control the tumors in the reported experiments.
- Treated mice rejected a second introduction of DMG cells nearly seven weeks later, and B-SYNC cells remained functional for more than 70 days.
- The findings come from mouse studies; safety and effectiveness in people remain unknown.
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