Antidepressant side effects differ greatly depending on the drug, study finds
Summary
A UK study examined side effects of 30 antidepressants, comparing how each affects weight, heart rate, and more. SSRIs, common in the U.S., generally had fewer side effects than older drugs. The study aims to help personalize antidepressant treatment based on individual health needs.Key Facts
- The study analyzed data from over 150 clinical trials involving more than 58,000 patients.
- Selective Serotonin Reuptake Inhibitors (SSRIs) like Zoloft and Prozac showed fewer side effects compared to older antidepressants.
- The study examined how different antidepressants affect weight, blood pressure, and cholesterol, among other health areas.
- Nortriptyline, an older drug, could increase heart rate significantly compared to SSRIs.
- Results showed a potential average weight change of up to four pounds, depending on the medication.
- A free digital tool was developed to help doctors and patients choose medications based on desired side effect profiles.
- The study used mostly data from 8-week trials, not long-term use data, which is a limitation.
- Common side effects like impacts on sexual function were not included in the study's analysis.
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