Part-human part-mouse brain developed in science breakthrough
Summary
Scientists in the US have created mice with partly human brains by implanting human brain cells into genetically modified mice. This new method aims to help researchers study brain diseases that affect only humans and develop better treatments.Key Facts
- Researchers genetically engineered mice to have little or no own cerebral cortex, the brain area involved in thinking and senses.
- Human skin cells were reprogrammed to grow into brain-like tissue called organoids.
- These organoids were implanted into the mouse brains, where they connected with mouse brain circuits and spinal cord.
- After months, the human cells functioned similarly to the mouse brain’s outer layer.
- Behavioral tests showed the modified mice acted like normal mice, without improved thinking.
- The research was published in the journal Nature and reviewed by ethical experts.
- This model can help study conditions like epilepsy, autism, and cerebral palsy that are hard to replicate in mice.
- The goal is to better understand human brain disorders and improve drug testing success rates.
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